These draft guidelines provide practical information for providers and recipients of GRs and relevant policy and legal information. They illustrate the practical IP issues that providers and recipients are likely to face when negotiating an agreement, contract or license, and thereby enhance the information available to stakeholders assessing their IP options when considering access and benefit-sharing. They have informal status only, and do not offer authoritative legal advice nor set a policy direction. The present document introduces into the context of agreements on access and equitable benefit-sharing, and the role IP plays (Part I), sets out the main ideas behind the guidelines in its general provisions (Part II) and identifies the main preliminary steps for IP negotiations (Part III). In its main part, it develops the specific IP issues (Part IV) including overall IP issues (A), specific IP rights and issues (B) as well as licensing issues (C). Further, it refers to Model IP Clauses (Part V) and adds some considerations for developing sectoral approaches (Part VI).